PIG11 over-expression predicts good prognosis and induces HepG2 cell apoptosis via reactive oxygen species-dependent mitochondrial pathway. | Semantic Scholar (2024)

PIG11 expression may be associated with the malignancy of GC and may serve as a potential diagnostic and prognostic biomarker for GC.

MiR-645 expression is upregulated in NSCLC tissues and cells, and the proliferation and migration ofNSCLC cells are promoted by targeted regulation on the TP53I11 expression.

Results showed that FIBCD1 expression was higher in HCC and was associated with tumor diameter and vascular invasion, and may be a novel biomarker for prognosis evaluation of HCC.

Compound 9m could be a promising candidate for the treatment of drug-resistant cancer cells and, as such, warrants further investigation.

Compound 10 e, with prominent tumor selectivity and water solubility, could be a promising candidate for the treatment of cancer and, as such, warrants further investigation.

Compound 11 at 5 mg/kg displayed potent antitumor activity in vivo with tumor suppression of 76% (w/w) and may represent a promising candidate drug for the chemotherapy of drug-resistant hepatocellular carcinoma and warrant more intensive study.

The mechanism of LBP action in radiation - exposed mouse BMNCs cells seems to involve inhibition of the mitochondrial apoptosis pathway.

The novel canthin-6-one derivative 8h with N-methyl piperazine represents a promising anticancer candidate and warrants a more intensive study.

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PIG11 is considered to be a new candidate liver tumour suppressor gene, and may play an important role in tumour suppression through promotion of cell apoptosis and the development of hepatocarcinoma.

PIG11 expression was significantly downregulated in HCC tissue and the cell lines and HepG2 cells were more sensitive to As2O3-induced apoptosis than L-02 cells, suggesting that the adaptive response of Pig11 expression is one of the important factors in enhancing cell sensitivity to As 2O3's apoptosis.

PIG11, a p53-induced gene, was upregulated markedly by As2O3 using the technique of differential display reverse transcriptase PCR (DDRT-PCR), and results suggest that PIG 11, as a downstream target of p53, is involved in apoptosis of MGC-803 cells.

Examination of transcripts induced by p53 expression before the onset of apoptosis stimulated additional biochemical and pharmacological experiments suggesting that p53 results in apoptosis through a three-step process: the transcriptional induction of redox-related genes; the formation of reactive oxygen species; and the oxidative degradation of mitochondrial components, culminating in cell death.

It is demonstrated that juglanin could be a promising candidate against human lung cancer progression and improved ROS and induced autophagy.

It is shown that PT treatment time- and dose-dependently enhanced the endoplasmic reticulum stress (ERS) signaling, thus decreasing the cell viability and inducing apoptosis in human PC9 and A549 NSCLC cell lines, and ERS activation may represent a new mechanism of anti-NSCLC action by PT.

The correlation between the expression of FOXC1 and tumor behaviors is reviewed and the mechanisms of the regulation of FoxC1 expression and activity in physiological and pathological conditions are summarized.

Findings suggested that KGM is a potential anti-cancer compound/drug entity, which could be an alternative preventive agent against liver cancer.

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